Human Telomere Length Correlates to the Size of the Associated Chromosome Arm

The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relativ...

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Autores principales: Wise, Jasen L., Crout, Richard J., McNeil, Daniel W., Weyant, Robert J., Marazita, Mary L., Wenger, Sharon L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695537/
https://www.ncbi.nlm.nih.gov/pubmed/19547752
http://dx.doi.org/10.1371/journal.pone.0006013
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author Wise, Jasen L.
Crout, Richard J.
McNeil, Daniel W.
Weyant, Robert J.
Marazita, Mary L.
Wenger, Sharon L.
author_facet Wise, Jasen L.
Crout, Richard J.
McNeil, Daniel W.
Weyant, Robert J.
Marazita, Mary L.
Wenger, Sharon L.
author_sort Wise, Jasen L.
collection PubMed
description The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from http://www.ncbi.nlm.nih.gov/projects/mapview/.
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spelling pubmed-26955372009-06-23 Human Telomere Length Correlates to the Size of the Associated Chromosome Arm Wise, Jasen L. Crout, Richard J. McNeil, Daniel W. Weyant, Robert J. Marazita, Mary L. Wenger, Sharon L. PLoS One Research Article The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from http://www.ncbi.nlm.nih.gov/projects/mapview/. Public Library of Science 2009-06-23 /pmc/articles/PMC2695537/ /pubmed/19547752 http://dx.doi.org/10.1371/journal.pone.0006013 Text en Wise et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wise, Jasen L.
Crout, Richard J.
McNeil, Daniel W.
Weyant, Robert J.
Marazita, Mary L.
Wenger, Sharon L.
Human Telomere Length Correlates to the Size of the Associated Chromosome Arm
title Human Telomere Length Correlates to the Size of the Associated Chromosome Arm
title_full Human Telomere Length Correlates to the Size of the Associated Chromosome Arm
title_fullStr Human Telomere Length Correlates to the Size of the Associated Chromosome Arm
title_full_unstemmed Human Telomere Length Correlates to the Size of the Associated Chromosome Arm
title_short Human Telomere Length Correlates to the Size of the Associated Chromosome Arm
title_sort human telomere length correlates to the size of the associated chromosome arm
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695537/
https://www.ncbi.nlm.nih.gov/pubmed/19547752
http://dx.doi.org/10.1371/journal.pone.0006013
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