Increased Frequency and Compromised Function of T Regulatory Cells in Systemic Sclerosis (SSc) Is Related to a Diminished CD69 and TGFβ Expression

BACKGROUND: Regulatory T cells (Tregs) are essential in the control of tolerance. Evidence implicates Tregs in human autoimmune conditions. Here we investigated their role in systemic sclerosis (SSc). METHODS/PRINCIPAL FINDINGS: Patients were subdivided as having limited cutaneous SSc (lcSSc, n = 20...

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Detalles Bibliográficos
Autores principales: Radstake, Timothy R. D. J., van Bon, Lenny, Broen, Jasper, Wenink, Mark, Santegoets, Kim, Deng, Yanhui, Hussaini, Anila, Simms, Robert, Cruikshank, William W., Lafyatis, Robert
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695559/
https://www.ncbi.nlm.nih.gov/pubmed/19543397
http://dx.doi.org/10.1371/journal.pone.0005981

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