When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation

The CNS (central nervous system) is unquestionably the central organ that regulates directly or indirectly all physiological systems in the mammalian body. Yet, when considering the defence of the CNS from pathogens, the CNS has often been considered passive and subservient to the pro-inflammatory r...

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Detalles Bibliográficos
Autores principales: Davis, Deirdre S, Carson, Monica J
Formato: Texto
Lenguaje:English
Publicado: American Society for Neurochemistry 2009
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695584/
https://www.ncbi.nlm.nih.gov/pubmed/19570029
http://dx.doi.org/10.1042/AN20090024
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author Davis, Deirdre S
Carson, Monica J
author_facet Davis, Deirdre S
Carson, Monica J
author_sort Davis, Deirdre S
collection PubMed
description The CNS (central nervous system) is unquestionably the central organ that regulates directly or indirectly all physiological systems in the mammalian body. Yet, when considering the defence of the CNS from pathogens, the CNS has often been considered passive and subservient to the pro-inflammatory responses of the immune system. In this view, neuroinflammatory disorders are examples of when the tail (the immune system) wags the dog (the CNS) to the detriment of an individual's function and survival.
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spelling pubmed-26955842009-06-23 When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation Davis, Deirdre S Carson, Monica J ASN Neuro Commentary The CNS (central nervous system) is unquestionably the central organ that regulates directly or indirectly all physiological systems in the mammalian body. Yet, when considering the defence of the CNS from pathogens, the CNS has often been considered passive and subservient to the pro-inflammatory responses of the immune system. In this view, neuroinflammatory disorders are examples of when the tail (the immune system) wags the dog (the CNS) to the detriment of an individual's function and survival. American Society for Neurochemistry 2009-05-05 /pmc/articles/PMC2695584/ /pubmed/19570029 http://dx.doi.org/10.1042/AN20090024 Text en © 2009 The Author(s). http://creativecommons.org/licenses/by-nc/2.5/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commerical use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Davis, Deirdre S
Carson, Monica J
When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation
title When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation
title_full When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation
title_fullStr When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation
title_full_unstemmed When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation
title_short When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation
title_sort when the tail can't wag the dog: the implications of cns-intrinsic initiation of neuroinflammation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695584/
https://www.ncbi.nlm.nih.gov/pubmed/19570029
http://dx.doi.org/10.1042/AN20090024
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