MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses

MyD88 KO (knockout) mice are exquisitely sensitive to CNS (central nervous system) infection with Staphylococcus aureus, a common aetiological agent of brain abscess, exhibiting global defects in innate immunity and exacerbated tissue damage. However, since brain abscesses are typified by the involv...

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Detalles Bibliográficos
Autores principales: Garg, Sarita, Nichols, Jessica R, Esen, Nilufer, Liu, Shuliang, Phulwani, Nirmal K, Syed, Mohsin Md., Wood, William H, Zhang, Yongqing, Becker, Kevin G, Aldrich, Amy, Kielian, Tammy
Formato: Texto
Lenguaje:English
Publicado: American Society for Neurochemistry 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695586/
https://www.ncbi.nlm.nih.gov/pubmed/19570030
http://dx.doi.org/10.1042/AN20090004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695586/
https://www.ncbi.nlm.nih.gov/pubmed/19570030
http://dx.doi.org/10.1042/AN20090004

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