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Can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? Modelling study based on the Norwegian HUNT 2 population

RATIONALE, AIMS AND OBJECTIVES: Clinicians are generally advised to consider several risk factors when evaluating patients' cardiovascular disease (CVD) risk. Our aim was to study whether combined assessment of five traditional risk factors might help doctors demarcate a relatively distinct and...

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Detalles Bibliográficos
Autores principales: Petursson, Halfdan, Getz, Linn, Sigurdsson, Johann A, Hetlevik, Irene
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695852/
https://www.ncbi.nlm.nih.gov/pubmed/19239589
http://dx.doi.org/10.1111/j.1365-2753.2008.00962.x
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author Petursson, Halfdan
Getz, Linn
Sigurdsson, Johann A
Hetlevik, Irene
author_facet Petursson, Halfdan
Getz, Linn
Sigurdsson, Johann A
Hetlevik, Irene
author_sort Petursson, Halfdan
collection PubMed
description RATIONALE, AIMS AND OBJECTIVES: Clinicians are generally advised to consider several risk factors when evaluating patients' cardiovascular disease (CVD) risk. Our aim was to study whether combined assessment of five traditional risk factors might help doctors demarcate a relatively distinct and manageable group of high-risk individuals. We selected five modifiable risk factors and estimated the proportion of a well-defined population with ‘unfavourable’ levels of at least two of them, as defined by four internationally renowned guidelines. The impact of including so-called ‘prehypertension’ among the risk factors was specifically addressed, and the results are discussed in a wider perspective. MATERIAL AND METHODS: Guideline implementation was modelled on data from a cross-sectional Norwegian population study comprising 62 104 adults aged 20–79 years (The Nord-Tröndelag Health Study 1995–7). Total, age- and gender-specific point prevalences of individuals with zero, one, two, three or more factors, in addition to established disease, were calculated. RESULTS: One single CVD risk factor was exhibited by 12.4% of the population; two factors by 21.5%; and three or more by 49.7%. Established CVD or diabetes mellitus was reported by 12.5%. In total, 83.7% of the population exhibited a risk or disease profile with at least two factors, if prehypertension was included. CONCLUSIONS: If guideline recommendations are literally applied, as many as 84% of adults in Norway could exhibit two or more CVD or risk factors and thus be considered in need of individual, clinical attention. This challenges the widely held presumption that ‘the net will close’ around a manageable group of individuals-at-risk if several risk factors are jointly considered. As the finding of this study arises in one of the world's most long- and healthy-living populations, it raises several practical as well as ethical questions.
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spelling pubmed-26958522009-06-16 Can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? Modelling study based on the Norwegian HUNT 2 population Petursson, Halfdan Getz, Linn Sigurdsson, Johann A Hetlevik, Irene J Eval Clin Pract Original Articles RATIONALE, AIMS AND OBJECTIVES: Clinicians are generally advised to consider several risk factors when evaluating patients' cardiovascular disease (CVD) risk. Our aim was to study whether combined assessment of five traditional risk factors might help doctors demarcate a relatively distinct and manageable group of high-risk individuals. We selected five modifiable risk factors and estimated the proportion of a well-defined population with ‘unfavourable’ levels of at least two of them, as defined by four internationally renowned guidelines. The impact of including so-called ‘prehypertension’ among the risk factors was specifically addressed, and the results are discussed in a wider perspective. MATERIAL AND METHODS: Guideline implementation was modelled on data from a cross-sectional Norwegian population study comprising 62 104 adults aged 20–79 years (The Nord-Tröndelag Health Study 1995–7). Total, age- and gender-specific point prevalences of individuals with zero, one, two, three or more factors, in addition to established disease, were calculated. RESULTS: One single CVD risk factor was exhibited by 12.4% of the population; two factors by 21.5%; and three or more by 49.7%. Established CVD or diabetes mellitus was reported by 12.5%. In total, 83.7% of the population exhibited a risk or disease profile with at least two factors, if prehypertension was included. CONCLUSIONS: If guideline recommendations are literally applied, as many as 84% of adults in Norway could exhibit two or more CVD or risk factors and thus be considered in need of individual, clinical attention. This challenges the widely held presumption that ‘the net will close’ around a manageable group of individuals-at-risk if several risk factors are jointly considered. As the finding of this study arises in one of the world's most long- and healthy-living populations, it raises several practical as well as ethical questions. Blackwell Publishing Ltd 2009-02 /pmc/articles/PMC2695852/ /pubmed/19239589 http://dx.doi.org/10.1111/j.1365-2753.2008.00962.x Text en Journal compilation © 2009 Blackwell Publishing Ltd
spellingShingle Original Articles
Petursson, Halfdan
Getz, Linn
Sigurdsson, Johann A
Hetlevik, Irene
Can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? Modelling study based on the Norwegian HUNT 2 population
title Can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? Modelling study based on the Norwegian HUNT 2 population
title_full Can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? Modelling study based on the Norwegian HUNT 2 population
title_fullStr Can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? Modelling study based on the Norwegian HUNT 2 population
title_full_unstemmed Can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? Modelling study based on the Norwegian HUNT 2 population
title_short Can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? Modelling study based on the Norwegian HUNT 2 population
title_sort can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? modelling study based on the norwegian hunt 2 population
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695852/
https://www.ncbi.nlm.nih.gov/pubmed/19239589
http://dx.doi.org/10.1111/j.1365-2753.2008.00962.x
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