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Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam

BACKGROUND: Streptococcus suis can cause severe systemic infection in adults exposed to infected pigs or after consumption of undercooked pig products. S. suis is often misdiagnosed, due to lack of awareness and improper testing. Here we report the first fifty cases diagnosed with S. suis infection...

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Autores principales: Wertheim, Heiman F. L., Nguyen, Huyen Nguyen, Taylor, Walter, Lien, Trinh Thi Minh, Ngo, Hoa Thi, Nguyen, Thai Quoc, Nguyen, Bich Ngoc Thi, Nguyen, Ha Hong, Nguyen, Ha Minh, Nguyen, Cap Trung, Dao, Trinh Tuyet, Nguyen, Trung Vu, Fox, Annette, Farrar, Jeremy, Schultsz, Constance, Nguyen, Hien Duc, Nguyen, Kinh Van, Horby, Peter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696092/
https://www.ncbi.nlm.nih.gov/pubmed/19543404
http://dx.doi.org/10.1371/journal.pone.0005973
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author Wertheim, Heiman F. L.
Nguyen, Huyen Nguyen
Taylor, Walter
Lien, Trinh Thi Minh
Ngo, Hoa Thi
Nguyen, Thai Quoc
Nguyen, Bich Ngoc Thi
Nguyen, Ha Hong
Nguyen, Ha Minh
Nguyen, Cap Trung
Dao, Trinh Tuyet
Nguyen, Trung Vu
Fox, Annette
Farrar, Jeremy
Schultsz, Constance
Nguyen, Hien Duc
Nguyen, Kinh Van
Horby, Peter
author_facet Wertheim, Heiman F. L.
Nguyen, Huyen Nguyen
Taylor, Walter
Lien, Trinh Thi Minh
Ngo, Hoa Thi
Nguyen, Thai Quoc
Nguyen, Bich Ngoc Thi
Nguyen, Ha Hong
Nguyen, Ha Minh
Nguyen, Cap Trung
Dao, Trinh Tuyet
Nguyen, Trung Vu
Fox, Annette
Farrar, Jeremy
Schultsz, Constance
Nguyen, Hien Duc
Nguyen, Kinh Van
Horby, Peter
author_sort Wertheim, Heiman F. L.
collection PubMed
description BACKGROUND: Streptococcus suis can cause severe systemic infection in adults exposed to infected pigs or after consumption of undercooked pig products. S. suis is often misdiagnosed, due to lack of awareness and improper testing. Here we report the first fifty cases diagnosed with S. suis infection in northern Viet Nam. METHODOLOGY/PRINCIPAL FINDINGS: In 2007, diagnostics for S. suis were set up at a national hospital in Hanoi. That year there were 43 S. suis positive cerebrospinal fluid samples, of which S. suis could be cultured in 32 cases and 11 cases were only positive by PCR. Seven patients were blood culture positive for S. suis but CSF culture and PCR negative; making a total of 50 patients with laboratory confirmed S. suis infection in 2007. The number of S. suis cases peaked during the warmer months. CONCLUSIONS/SIGNIFICANCE: S. suis was commonly diagnosed as a cause of bacterial meningitis in adults in northern Viet Nam. In countries where there is intense and widespread exposure of humans to pigs, S. suis can be an important human pathogen.
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spelling pubmed-26960922009-06-22 Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam Wertheim, Heiman F. L. Nguyen, Huyen Nguyen Taylor, Walter Lien, Trinh Thi Minh Ngo, Hoa Thi Nguyen, Thai Quoc Nguyen, Bich Ngoc Thi Nguyen, Ha Hong Nguyen, Ha Minh Nguyen, Cap Trung Dao, Trinh Tuyet Nguyen, Trung Vu Fox, Annette Farrar, Jeremy Schultsz, Constance Nguyen, Hien Duc Nguyen, Kinh Van Horby, Peter PLoS One Research Article BACKGROUND: Streptococcus suis can cause severe systemic infection in adults exposed to infected pigs or after consumption of undercooked pig products. S. suis is often misdiagnosed, due to lack of awareness and improper testing. Here we report the first fifty cases diagnosed with S. suis infection in northern Viet Nam. METHODOLOGY/PRINCIPAL FINDINGS: In 2007, diagnostics for S. suis were set up at a national hospital in Hanoi. That year there were 43 S. suis positive cerebrospinal fluid samples, of which S. suis could be cultured in 32 cases and 11 cases were only positive by PCR. Seven patients were blood culture positive for S. suis but CSF culture and PCR negative; making a total of 50 patients with laboratory confirmed S. suis infection in 2007. The number of S. suis cases peaked during the warmer months. CONCLUSIONS/SIGNIFICANCE: S. suis was commonly diagnosed as a cause of bacterial meningitis in adults in northern Viet Nam. In countries where there is intense and widespread exposure of humans to pigs, S. suis can be an important human pathogen. Public Library of Science 2009-06-22 /pmc/articles/PMC2696092/ /pubmed/19543404 http://dx.doi.org/10.1371/journal.pone.0005973 Text en Wertheim et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wertheim, Heiman F. L.
Nguyen, Huyen Nguyen
Taylor, Walter
Lien, Trinh Thi Minh
Ngo, Hoa Thi
Nguyen, Thai Quoc
Nguyen, Bich Ngoc Thi
Nguyen, Ha Hong
Nguyen, Ha Minh
Nguyen, Cap Trung
Dao, Trinh Tuyet
Nguyen, Trung Vu
Fox, Annette
Farrar, Jeremy
Schultsz, Constance
Nguyen, Hien Duc
Nguyen, Kinh Van
Horby, Peter
Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam
title Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam
title_full Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam
title_fullStr Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam
title_full_unstemmed Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam
title_short Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam
title_sort streptococcus suis, an important cause of adult bacterial meningitis in northern vietnam
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696092/
https://www.ncbi.nlm.nih.gov/pubmed/19543404
http://dx.doi.org/10.1371/journal.pone.0005973
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