Frequent somatic mutations of GNAQ in uveal melanoma and blue nevi

BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures and lead to constitutive activation of the MAP-kinase pathway1, 2. However, BRAF and NRAS mutations are absent in a number of other melanocytic neopl...

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Detalles Bibliográficos
Autores principales: Van Raamsdonk, Catherine D., Bezrookove, Vladimir, Green, Gary, Bauer, Jürgen, Gaugler, Lona, O’Brien, Joan M., Simpson, Elizabeth M., Barsh, Gregory S., Bastian, Boris C.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696133/
https://www.ncbi.nlm.nih.gov/pubmed/19078957
http://dx.doi.org/10.1038/nature07586

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