Comparative genomics: From genotype to disease phenotype in the leishmaniases

Recent progress in sequencing the genomes of several Leishmania species, causative agents of cutaneous, mucocutaneous and visceral leishmaniasis, is revealing unusual features of potential relevance to parasite virulence and pathogenesis in the host. While the genomes of Leishmania major, Leishmania...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Deborah F., Peacock, Christopher S., Cruz, Angela K.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696322/
https://www.ncbi.nlm.nih.gov/pubmed/17645880
http://dx.doi.org/10.1016/j.ijpara.2007.05.015
_version_ 1782168256038043648
author Smith, Deborah F.
Peacock, Christopher S.
Cruz, Angela K.
author_facet Smith, Deborah F.
Peacock, Christopher S.
Cruz, Angela K.
author_sort Smith, Deborah F.
collection PubMed
description Recent progress in sequencing the genomes of several Leishmania species, causative agents of cutaneous, mucocutaneous and visceral leishmaniasis, is revealing unusual features of potential relevance to parasite virulence and pathogenesis in the host. While the genomes of Leishmania major, Leishmania braziliensis and Leishmania infantum are highly similar in content and organisation, species-specific genes and mechanisms distinguish one from another. In particular, the presence of retrotransposons and the components of a putative RNA interference machinery in L. braziliensis suggest the potential for both greater diversity and more tractable experimentation in this Leishmania Viannia species.
format Text
id pubmed-2696322
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Elsevier Science
record_format MEDLINE/PubMed
spelling pubmed-26963222009-06-15 Comparative genomics: From genotype to disease phenotype in the leishmaniases Smith, Deborah F. Peacock, Christopher S. Cruz, Angela K. Int J Parasitol Invited Review Recent progress in sequencing the genomes of several Leishmania species, causative agents of cutaneous, mucocutaneous and visceral leishmaniasis, is revealing unusual features of potential relevance to parasite virulence and pathogenesis in the host. While the genomes of Leishmania major, Leishmania braziliensis and Leishmania infantum are highly similar in content and organisation, species-specific genes and mechanisms distinguish one from another. In particular, the presence of retrotransposons and the components of a putative RNA interference machinery in L. braziliensis suggest the potential for both greater diversity and more tractable experimentation in this Leishmania Viannia species. Elsevier Science 2007-09 /pmc/articles/PMC2696322/ /pubmed/17645880 http://dx.doi.org/10.1016/j.ijpara.2007.05.015 Text en © 2007 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Invited Review
Smith, Deborah F.
Peacock, Christopher S.
Cruz, Angela K.
Comparative genomics: From genotype to disease phenotype in the leishmaniases
title Comparative genomics: From genotype to disease phenotype in the leishmaniases
title_full Comparative genomics: From genotype to disease phenotype in the leishmaniases
title_fullStr Comparative genomics: From genotype to disease phenotype in the leishmaniases
title_full_unstemmed Comparative genomics: From genotype to disease phenotype in the leishmaniases
title_short Comparative genomics: From genotype to disease phenotype in the leishmaniases
title_sort comparative genomics: from genotype to disease phenotype in the leishmaniases
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696322/
https://www.ncbi.nlm.nih.gov/pubmed/17645880
http://dx.doi.org/10.1016/j.ijpara.2007.05.015
work_keys_str_mv AT smithdeborahf comparativegenomicsfromgenotypetodiseasephenotypeintheleishmaniases
AT peacockchristophers comparativegenomicsfromgenotypetodiseasephenotypeintheleishmaniases
AT cruzangelak comparativegenomicsfromgenotypetodiseasephenotypeintheleishmaniases