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Compensatory evolution for a gene deletion is not limited to its immediate functional network

BACKGROUND: Genetic disruption of an important phenotype should favor compensatory mutations that restore the phenotype. If the genetic basis of the phenotype is modular, with a network of interacting genes whose functions are specific to that phenotype, compensatory mutations are expected among the...

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Detalles Bibliográficos
Autores principales: Harcombe, WR, Springman, R, Bull, JJ
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696425/
https://www.ncbi.nlm.nih.gov/pubmed/19445716
http://dx.doi.org/10.1186/1471-2148-9-106