A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice

BACKGROUND: Recent development in the field of COPD has focused on strategies aimed at reducing the underlying inflammation through selective inhibition of the phosphodiesterase type IV (PDE4) isoform. Although the anti-inflammatory and bronchodilator activity of selective PDE4 inhibitors has been w...

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Detalles Bibliográficos
Autores principales: Fortin, Marylène, D'Anjou, Hélène, Higgins, Marie-Ève, Gougeon, Jasmine, Aubé, Paméla, Moktefi, Kamel, Mouissi, Sonia, Séguin, Serge, Séguin, Rosanne, Renzi, Paolo M, Paquet, Luc, Ferrari, Nicolay
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696437/
https://www.ncbi.nlm.nih.gov/pubmed/19457265
http://dx.doi.org/10.1186/1465-9921-10-39

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