Diffuse Optical Tomography of the Breast: Initial Validation in Benign Cysts

PURPOSE: The purpose of this study was to validate a newly developed diffuse optical tomography (DOT) system on benign cysts in the breast. PROCEDURES: Eight patients with 20 benign cysts were included. Study procedures consisted of optical breast imaging and breast magnetic resonance imaging (MRI)...

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Detalles Bibliográficos
Autores principales: van de Ven, Stephanie, Elias, Sjoerd, Wiethoff, Andrea, van der Voort, Marjolein, Leproux, Anais, Nielsen, Tim, Brendel, Bernhard, Bakker, Leon, van der Mark, Martin, Mali, Willem, Luijten, Peter
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696611/
https://www.ncbi.nlm.nih.gov/pubmed/19030937
http://dx.doi.org/10.1007/s11307-008-0176-x
Descripción
Sumario:PURPOSE: The purpose of this study was to validate a newly developed diffuse optical tomography (DOT) system on benign cysts in the breast. PROCEDURES: Eight patients with 20 benign cysts were included. Study procedures consisted of optical breast imaging and breast magnetic resonance imaging (MRI) for comparison. A reconstruction algorithm computed three-dimensional images for each of the four near-infrared wavelengths used by our DOT system (Philips Healthcare, Best, The Netherlands). These images were combined using a spectroscopic model to assess tissue composition and lesion size. RESULTS: Twenty cysts were analyzed in eight patients. By using the spectroscopic information, 13 of 20 cysts (65%) were visualized with DOT, confirming their high water and low total hemoglobin content. Lesion size and location showed good agreement with MRI; Pearson correlation coefficient was 0.7 (p < 0.01). CONCLUSIONS: DOT can visualize benign cysts in the breast and elucidate their high water and low total hemoglobin content by spectroscopic analysis.

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