Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis

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The hypoxia-mediated response of tumours is a major determining factor in growth and metastasis. Understanding tumour biology under hypoxic conditions is crucial for the development of antiangiogenic therapy. Using one of the largest cohorts of rectal adenocarcinomas to date, this study investigated...

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Detalles Bibliográficos
Autores principales: Rasheed, S, Harris, A L, Tekkis, P P, Turley, H, Silver, A, McDonald, P J, Talbot, I C, Glynne-Jones, R, Northover, J M A, Guenther, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696753/
https://www.ncbi.nlm.nih.gov/pubmed/19436307
http://dx.doi.org/10.1038/sj.bjc.6605026

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