The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer

Expression of P3H2 (Leprel1) and P3H3 (Leprel2) but not P3H1 (Leprecan) is down-regulated in breast cancer by aberrant CpG methylation in the 5′ regulatory sequences of each gene. Methylation of P3H2 appears specific to breast cancer as no methylation was detected in a range of cell lines from other...

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Detalles Bibliográficos
Autores principales: Shah, R, Smith, P, Purdie, C, Quinlan, P, Baker, L, Aman, P, Thompson, A M, Crook, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696763/
https://www.ncbi.nlm.nih.gov/pubmed/19436308
http://dx.doi.org/10.1038/sj.bjc.6605042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696763/
https://www.ncbi.nlm.nih.gov/pubmed/19436308
http://dx.doi.org/10.1038/sj.bjc.6605042

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