Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, sho...

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Detalles Bibliográficos
Autores principales: Nilsson, J, Skog, J, Nordstrand, A, Baranov, V, Mincheva-Nilsson, L, Breakefield, X O, Widmark, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696767/
https://www.ncbi.nlm.nih.gov/pubmed/19401683
http://dx.doi.org/10.1038/sj.bjc.6605058
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author Nilsson, J
Skog, J
Nordstrand, A
Baranov, V
Mincheva-Nilsson, L
Breakefield, X O
Widmark, A
author_facet Nilsson, J
Skog, J
Nordstrand, A
Baranov, V
Mincheva-Nilsson, L
Breakefield, X O
Widmark, A
author_sort Nilsson, J
collection PubMed
description Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.
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spelling pubmed-26967672010-05-19 Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer Nilsson, J Skog, J Nordstrand, A Baranov, V Mincheva-Nilsson, L Breakefield, X O Widmark, A Br J Cancer Short Communication Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status. Nature Publishing Group 2009-05-19 2009-04-28 /pmc/articles/PMC2696767/ /pubmed/19401683 http://dx.doi.org/10.1038/sj.bjc.6605058 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Nilsson, J
Skog, J
Nordstrand, A
Baranov, V
Mincheva-Nilsson, L
Breakefield, X O
Widmark, A
Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
title Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
title_full Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
title_fullStr Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
title_full_unstemmed Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
title_short Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
title_sort prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696767/
https://www.ncbi.nlm.nih.gov/pubmed/19401683
http://dx.doi.org/10.1038/sj.bjc.6605058
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