A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length

BACKGROUND: Telomere length is a predictor for a number of common age related diseases and is a heritable trait. METHODS AND RESULTS: To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314 075 single nucleotide polymorphisms (SNPs) and...

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Detalles Bibliográficos
Autores principales: Mangino, M, Richards, J B, Soranzo, N, Zhai, G, Aviv, A, Valdes, A M, Samani, N J, Deloukas, P, Spector, T D
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2009
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696823/
https://www.ncbi.nlm.nih.gov/pubmed/19359265
http://dx.doi.org/10.1136/jmg.2008.064956
Descripción
Sumario:BACKGROUND: Telomere length is a predictor for a number of common age related diseases and is a heritable trait. METHODS AND RESULTS: To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314 075 single nucleotide polymorphisms (SNPs) and validated the results in a second cohort (n for both cohorts combined  =  2790). We identified two novel associated variants (rs2162440, p = 2.6×10(−6); and rs7235755, p = 5.5×10(−6)) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast. CONCLUSION: These results provide new insights into the pathways regulating telomere homeostasis in humans.

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