A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length

BACKGROUND: Telomere length is a predictor for a number of common age related diseases and is a heritable trait. METHODS AND RESULTS: To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314 075 single nucleotide polymorphisms (SNPs) and...

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Autores principales: Mangino, M, Richards, J B, Soranzo, N, Zhai, G, Aviv, A, Valdes, A M, Samani, N J, Deloukas, P, Spector, T D
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2009
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696823/
https://www.ncbi.nlm.nih.gov/pubmed/19359265
http://dx.doi.org/10.1136/jmg.2008.064956
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author Mangino, M
Richards, J B
Soranzo, N
Zhai, G
Aviv, A
Valdes, A M
Samani, N J
Deloukas, P
Spector, T D
author_facet Mangino, M
Richards, J B
Soranzo, N
Zhai, G
Aviv, A
Valdes, A M
Samani, N J
Deloukas, P
Spector, T D
author_sort Mangino, M
collection PubMed
description BACKGROUND: Telomere length is a predictor for a number of common age related diseases and is a heritable trait. METHODS AND RESULTS: To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314 075 single nucleotide polymorphisms (SNPs) and validated the results in a second cohort (n for both cohorts combined  =  2790). We identified two novel associated variants (rs2162440, p = 2.6×10(−6); and rs7235755, p = 5.5×10(−6)) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast. CONCLUSION: These results provide new insights into the pathways regulating telomere homeostasis in humans.
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spelling pubmed-26968232010-01-01 A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length Mangino, M Richards, J B Soranzo, N Zhai, G Aviv, A Valdes, A M Samani, N J Deloukas, P Spector, T D J Med Genet Short Reports BACKGROUND: Telomere length is a predictor for a number of common age related diseases and is a heritable trait. METHODS AND RESULTS: To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314 075 single nucleotide polymorphisms (SNPs) and validated the results in a second cohort (n for both cohorts combined  =  2790). We identified two novel associated variants (rs2162440, p = 2.6×10(−6); and rs7235755, p = 5.5×10(−6)) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast. CONCLUSION: These results provide new insights into the pathways regulating telomere homeostasis in humans. BMJ Publishing Group 2009-07 2009-04-24 /pmc/articles/PMC2696823/ /pubmed/19359265 http://dx.doi.org/10.1136/jmg.2008.064956 Text en © Mangino et al 2009 http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Mangino, M
Richards, J B
Soranzo, N
Zhai, G
Aviv, A
Valdes, A M
Samani, N J
Deloukas, P
Spector, T D
A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
title A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
title_full A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
title_fullStr A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
title_full_unstemmed A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
title_short A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
title_sort genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696823/
https://www.ncbi.nlm.nih.gov/pubmed/19359265
http://dx.doi.org/10.1136/jmg.2008.064956
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