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HIV interactions with monocytes and dendritic cells: viral latency and reservoirs
HIV is a devastating human pathogen that causes serious immunological diseases in humans around the world. The virus is able to remain latent in an infected host for many years, allowing for the long-term survival of the virus and inevitably prolonging the infection process. The location and mechani...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697150/ https://www.ncbi.nlm.nih.gov/pubmed/19486514 http://dx.doi.org/10.1186/1742-4690-6-51 |
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author | Coleman, Christopher M Wu, Li |
author_facet | Coleman, Christopher M Wu, Li |
author_sort | Coleman, Christopher M |
collection | PubMed |
description | HIV is a devastating human pathogen that causes serious immunological diseases in humans around the world. The virus is able to remain latent in an infected host for many years, allowing for the long-term survival of the virus and inevitably prolonging the infection process. The location and mechanisms of HIV latency are under investigation and remain important topics in the study of viral pathogenesis. Given that HIV is a blood-borne pathogen, a number of cell types have been proposed to be the sites of latency, including resting memory CD4(+ )T cells, peripheral blood monocytes, dendritic cells and macrophages in the lymph nodes, and haematopoietic stem cells in the bone marrow. This review updates the latest advances in the study of HIV interactions with monocytes and dendritic cells, and highlights the potential role of these cells as viral reservoirs and the effects of the HIV-host-cell interactions on viral pathogenesis. |
format | Text |
id | pubmed-2697150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26971502009-06-16 HIV interactions with monocytes and dendritic cells: viral latency and reservoirs Coleman, Christopher M Wu, Li Retrovirology Review HIV is a devastating human pathogen that causes serious immunological diseases in humans around the world. The virus is able to remain latent in an infected host for many years, allowing for the long-term survival of the virus and inevitably prolonging the infection process. The location and mechanisms of HIV latency are under investigation and remain important topics in the study of viral pathogenesis. Given that HIV is a blood-borne pathogen, a number of cell types have been proposed to be the sites of latency, including resting memory CD4(+ )T cells, peripheral blood monocytes, dendritic cells and macrophages in the lymph nodes, and haematopoietic stem cells in the bone marrow. This review updates the latest advances in the study of HIV interactions with monocytes and dendritic cells, and highlights the potential role of these cells as viral reservoirs and the effects of the HIV-host-cell interactions on viral pathogenesis. BioMed Central 2009-06-01 /pmc/articles/PMC2697150/ /pubmed/19486514 http://dx.doi.org/10.1186/1742-4690-6-51 Text en Copyright © 2009 Coleman and Wu; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Coleman, Christopher M Wu, Li HIV interactions with monocytes and dendritic cells: viral latency and reservoirs |
title | HIV interactions with monocytes and dendritic cells: viral latency and reservoirs |
title_full | HIV interactions with monocytes and dendritic cells: viral latency and reservoirs |
title_fullStr | HIV interactions with monocytes and dendritic cells: viral latency and reservoirs |
title_full_unstemmed | HIV interactions with monocytes and dendritic cells: viral latency and reservoirs |
title_short | HIV interactions with monocytes and dendritic cells: viral latency and reservoirs |
title_sort | hiv interactions with monocytes and dendritic cells: viral latency and reservoirs |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697150/ https://www.ncbi.nlm.nih.gov/pubmed/19486514 http://dx.doi.org/10.1186/1742-4690-6-51 |
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