Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

BACKGROUND: Nonsense-mediated decay is a mechanism that degrades mRNAs with a premature termination codon. That some exons have premature termination codons at fixation is paradoxical: why make a transcript if it is only to be destroyed? One model supposes that splicing is inherently noisy and spuri...

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Detalles Bibliográficos
Autores principales: Zhang, Zhenguo, Xin, Dedong, Wang, Ping, Zhou, Li, Hu, Landian, Kong, Xiangyin, Hurst, Laurence D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697156/
https://www.ncbi.nlm.nih.gov/pubmed/19442261
http://dx.doi.org/10.1186/1741-7007-7-23

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