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Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance

A method was developed to optimize simultaneous selection for a quantitative trait with a known QTL within a male and a female line to maximize crossbred performance from a two-way cross. Strategies to maximize cumulative discounted response in crossbred performance over ten generations were derived...

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Detalles Bibliográficos
Autores principales: Dekkers, Jack CM, Chakraborty, Reena
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697203/
https://www.ncbi.nlm.nih.gov/pubmed/15107268
http://dx.doi.org/10.1186/1297-9686-36-3-297
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author Dekkers, Jack CM
Chakraborty, Reena
author_facet Dekkers, Jack CM
Chakraborty, Reena
author_sort Dekkers, Jack CM
collection PubMed
description A method was developed to optimize simultaneous selection for a quantitative trait with a known QTL within a male and a female line to maximize crossbred performance from a two-way cross. Strategies to maximize cumulative discounted response in crossbred performance over ten generations were derived by optimizing weights in an index of a QTL and phenotype. Strategies were compared to selection on purebred phenotype. Extra responses were limited for QTL with additive and partial dominance effects, but substantial for QTL with over-dominance, for which optimal QTL selection resulted in differential selection in male and female lines to increase the frequency of heterozygotes and polygenic responses. For over-dominant QTL, maximization of crossbred performance one generation at a time resulted in similar responses as optimization across all generations and simultaneous optimal selection in a male and female line resulted in greater response than optimal selection within a single line without crossbreeding. Results show that strategic use of information on over-dominant QTL can enhance crossbred performance without crossbred testing.
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spelling pubmed-26972032009-06-16 Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance Dekkers, Jack CM Chakraborty, Reena Genet Sel Evol Research A method was developed to optimize simultaneous selection for a quantitative trait with a known QTL within a male and a female line to maximize crossbred performance from a two-way cross. Strategies to maximize cumulative discounted response in crossbred performance over ten generations were derived by optimizing weights in an index of a QTL and phenotype. Strategies were compared to selection on purebred phenotype. Extra responses were limited for QTL with additive and partial dominance effects, but substantial for QTL with over-dominance, for which optimal QTL selection resulted in differential selection in male and female lines to increase the frequency of heterozygotes and polygenic responses. For over-dominant QTL, maximization of crossbred performance one generation at a time resulted in similar responses as optimization across all generations and simultaneous optimal selection in a male and female line resulted in greater response than optimal selection within a single line without crossbreeding. Results show that strategic use of information on over-dominant QTL can enhance crossbred performance without crossbred testing. BioMed Central 2004-05-15 /pmc/articles/PMC2697203/ /pubmed/15107268 http://dx.doi.org/10.1186/1297-9686-36-3-297 Text en Copyright © 2004 INRA, EDP Sciences
spellingShingle Research
Dekkers, Jack CM
Chakraborty, Reena
Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance
title Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance
title_full Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance
title_fullStr Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance
title_full_unstemmed Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance
title_short Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance
title_sort optimizing purebred selection for crossbred performance using qtl with different degrees of dominance
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697203/
https://www.ncbi.nlm.nih.gov/pubmed/15107268
http://dx.doi.org/10.1186/1297-9686-36-3-297
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