A gene-based radiation hybrid map of chicken microchromosome 14: Comparison to human and alignment to the assembled chicken sequence

We present a gene-based RH map of the chicken microchromosome GGA14, known to have synteny conservations with human chromosomal regions HSA16p13.3 and HSA17p11.2. Microsatellite markers from the genetic map were used to check the validity of the RH map and additional markers were developed from chic...

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Detalles Bibliográficos
Autores principales: Morisson, Mireille, Leroux, Sophie, Jiguet-Jiglaire, Carine, Assaf, Sirine, Pitel, Frédérique, Lagarrigue, Sandrine, Bardes, Suzanne, Feve, Katia, Faraut, Thomas, Milan, Denis, Vignal, Alain
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697232/
https://www.ncbi.nlm.nih.gov/pubmed/16194526
http://dx.doi.org/10.1186/1297-9686-37-3-229
Descripción
Sumario:We present a gene-based RH map of the chicken microchromosome GGA14, known to have synteny conservations with human chromosomal regions HSA16p13.3 and HSA17p11.2. Microsatellite markers from the genetic map were used to check the validity of the RH map and additional markers were developed from chicken EST data to yield comparative mapping data. A high rate of intra-chromosomal rearrangements was detected by comparison to the assembled human sequence. Finally, the alignment of the RH map to the assembled chicken sequence showed a small number of discordances, most of which involved the same region of the chromosome spanning between 40.5 and 75.9 cR(6000 )on the RH map.

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