Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea

The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enh...

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Autores principales: van den Biggelaar, Anita. H.J., Richmond, Peter C., Pomat, William S., Phuanukoonnon, Suparat, Nadal-Sims, Marie A., Devitt, Catherine J., Siba, Peter M., Lehmann, Deborah, Holt, Patrick G.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697326/
https://www.ncbi.nlm.nih.gov/pubmed/19150378
http://dx.doi.org/10.1016/j.vaccine.2008.12.046
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author van den Biggelaar, Anita. H.J.
Richmond, Peter C.
Pomat, William S.
Phuanukoonnon, Suparat
Nadal-Sims, Marie A.
Devitt, Catherine J.
Siba, Peter M.
Lehmann, Deborah
Holt, Patrick G.
author_facet van den Biggelaar, Anita. H.J.
Richmond, Peter C.
Pomat, William S.
Phuanukoonnon, Suparat
Nadal-Sims, Marie A.
Devitt, Catherine J.
Siba, Peter M.
Lehmann, Deborah
Holt, Patrick G.
author_sort van den Biggelaar, Anita. H.J.
collection PubMed
description The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM(197) compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses.
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spelling pubmed-26973262009-06-23 Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea van den Biggelaar, Anita. H.J. Richmond, Peter C. Pomat, William S. Phuanukoonnon, Suparat Nadal-Sims, Marie A. Devitt, Catherine J. Siba, Peter M. Lehmann, Deborah Holt, Patrick G. Vaccine Article The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM(197) compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses. Elsevier Science 2009-02-25 /pmc/articles/PMC2697326/ /pubmed/19150378 http://dx.doi.org/10.1016/j.vaccine.2008.12.046 Text en © 2009 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
van den Biggelaar, Anita. H.J.
Richmond, Peter C.
Pomat, William S.
Phuanukoonnon, Suparat
Nadal-Sims, Marie A.
Devitt, Catherine J.
Siba, Peter M.
Lehmann, Deborah
Holt, Patrick G.
Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea
title Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea
title_full Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea
title_fullStr Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea
title_full_unstemmed Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea
title_short Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea
title_sort neonatal pneumococcal conjugate vaccine immunization primes t cells for preferential th2 cytokine expression: a randomized controlled trial in papua new guinea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697326/
https://www.ncbi.nlm.nih.gov/pubmed/19150378
http://dx.doi.org/10.1016/j.vaccine.2008.12.046
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