A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal Tumorigenesis

Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra-intestinal tumors. Moreover, somatic APC mutat...

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Detalles Bibliográficos
Autores principales: Gaspar, Claudia, Franken, Patrick, Molenaar, Lia, Breukel, Cor, van der Valk, Martin, Smits, Ron, Fodde, Riccardo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697381/
https://www.ncbi.nlm.nih.gov/pubmed/19578404
http://dx.doi.org/10.1371/journal.pgen.1000547

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