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Investigating the Conformational Stability of Prion Strains through a Kinetic Replication Model
Prion proteins are known to misfold into a range of different aggregated forms, showing different phenotypic and pathological states. Understanding strain specificities is an important problem in the field of prion disease. Little is known about which PrP(Sc) structural properties and molecular mech...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697384/ https://www.ncbi.nlm.nih.gov/pubmed/19578427 http://dx.doi.org/10.1371/journal.pcbi.1000420 |