Cargando…

Selection against genetic defects in conservation schemes while controlling inbreeding

We studied different genetic models and evaluation systems to select against a genetic disease with additive, recessive or polygenic inheritance in genetic conservation schemes. When using optimum contribution selection with a restriction on the rate of inbreeding (ΔF) to select against a disease al...

Descripción completa

Detalles Bibliográficos
Autores principales: Sonesson, Anna K, Janss, Luc LG, Meuwissen, Theo HE
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697992/
https://www.ncbi.nlm.nih.gov/pubmed/12927071
http://dx.doi.org/10.1186/1297-9686-35-5-353
_version_ 1782168358270009344
author Sonesson, Anna K
Janss, Luc LG
Meuwissen, Theo HE
author_facet Sonesson, Anna K
Janss, Luc LG
Meuwissen, Theo HE
author_sort Sonesson, Anna K
collection PubMed
description We studied different genetic models and evaluation systems to select against a genetic disease with additive, recessive or polygenic inheritance in genetic conservation schemes. When using optimum contribution selection with a restriction on the rate of inbreeding (ΔF) to select against a disease allele, selection directly on DNA-genotypes is, as expected, the most efficient strategy. Selection for BLUP or segregation analysis breeding value estimates both need 1–2 generations more to halve the frequency of the disease allele, while these methods do not require knowledge of the disease mutation at the DNA level. BLUP and segregation analysis methods were equally efficient when selecting against a disease with single gene or complex polygene inheritance, i.e. knowledge about the mode of inheritance of the disease was not needed for efficient selection against the disease. Smaller schemes or schemes with a more stringent restriction on ΔF needed more generations to halve the frequency of the disease alleles or the fraction of diseased animals. Optimum contribution selection maintained ΔF at its predefined level, even when selection of females was at random. It is argued that in the investigated small conservation schemes with selection against a genetic defect, control of ΔF is very important.
format Text
id pubmed-2697992
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-26979922009-06-18 Selection against genetic defects in conservation schemes while controlling inbreeding Sonesson, Anna K Janss, Luc LG Meuwissen, Theo HE Genet Sel Evol Research We studied different genetic models and evaluation systems to select against a genetic disease with additive, recessive or polygenic inheritance in genetic conservation schemes. When using optimum contribution selection with a restriction on the rate of inbreeding (ΔF) to select against a disease allele, selection directly on DNA-genotypes is, as expected, the most efficient strategy. Selection for BLUP or segregation analysis breeding value estimates both need 1–2 generations more to halve the frequency of the disease allele, while these methods do not require knowledge of the disease mutation at the DNA level. BLUP and segregation analysis methods were equally efficient when selecting against a disease with single gene or complex polygene inheritance, i.e. knowledge about the mode of inheritance of the disease was not needed for efficient selection against the disease. Smaller schemes or schemes with a more stringent restriction on ΔF needed more generations to halve the frequency of the disease alleles or the fraction of diseased animals. Optimum contribution selection maintained ΔF at its predefined level, even when selection of females was at random. It is argued that in the investigated small conservation schemes with selection against a genetic defect, control of ΔF is very important. BioMed Central 2003-07-15 /pmc/articles/PMC2697992/ /pubmed/12927071 http://dx.doi.org/10.1186/1297-9686-35-5-353 Text en Copyright © 2003 INRA, EDP Sciences
spellingShingle Research
Sonesson, Anna K
Janss, Luc LG
Meuwissen, Theo HE
Selection against genetic defects in conservation schemes while controlling inbreeding
title Selection against genetic defects in conservation schemes while controlling inbreeding
title_full Selection against genetic defects in conservation schemes while controlling inbreeding
title_fullStr Selection against genetic defects in conservation schemes while controlling inbreeding
title_full_unstemmed Selection against genetic defects in conservation schemes while controlling inbreeding
title_short Selection against genetic defects in conservation schemes while controlling inbreeding
title_sort selection against genetic defects in conservation schemes while controlling inbreeding
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697992/
https://www.ncbi.nlm.nih.gov/pubmed/12927071
http://dx.doi.org/10.1186/1297-9686-35-5-353
work_keys_str_mv AT sonessonannak selectionagainstgeneticdefectsinconservationschemeswhilecontrollinginbreeding
AT janssluclg selectionagainstgeneticdefectsinconservationschemeswhilecontrollinginbreeding
AT meuwissentheohe selectionagainstgeneticdefectsinconservationschemeswhilecontrollinginbreeding