Cargando…

Pedigree and marker information requirements to monitor genetic variability

There are several measures available to describe the genetic variability of populations. The average inbreeding coefficient of a population based on pedigree information is a frequently chosen option. Due to the developments in molecular genetics it is also possible to calculate inbreeding coefficie...

Descripción completa

Detalles Bibliográficos
Autores principales: Roswitha, Baumung, Johann, Sölkner
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697993/
https://www.ncbi.nlm.nih.gov/pubmed/12927072
http://dx.doi.org/10.1186/1297-9686-35-5-369
_version_ 1782168358516424704
author Roswitha, Baumung
Johann, Sölkner
author_facet Roswitha, Baumung
Johann, Sölkner
author_sort Roswitha, Baumung
collection PubMed
description There are several measures available to describe the genetic variability of populations. The average inbreeding coefficient of a population based on pedigree information is a frequently chosen option. Due to the developments in molecular genetics it is also possible to calculate inbreeding coefficients based on genetic marker information. A simulation study was carried out involving ten sires and 50 dams. The animals were mated over a period of 20 discrete generations. The population size was kept constant. Different situations with regard to the level of polymorphism and initial allele frequencies and mating scheme (random mating, avoidance of full sib mating, avoidance of full sib and half sib mating) were considered. Pedigree inbreeding coefficients of the last generation using full pedigree or 10, 5 and 2 generations of the pedigree were calculated. Marker inbreeding coefficients based on different sets of microsatellite loci were also investigated. Under random mating, pedigree-inbreeding coefficients are clearly more closely related to true autozygosity (i.e., the actual proportion of loci with alleles identical by descent) than marker-inbreeding coefficients. If mating is not random, the demands on the quality and quantity of pedigree records increase. Greater attention must be paid to the correct parentage of the animals.
format Text
id pubmed-2697993
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-26979932009-06-18 Pedigree and marker information requirements to monitor genetic variability Roswitha, Baumung Johann, Sölkner Genet Sel Evol Research There are several measures available to describe the genetic variability of populations. The average inbreeding coefficient of a population based on pedigree information is a frequently chosen option. Due to the developments in molecular genetics it is also possible to calculate inbreeding coefficients based on genetic marker information. A simulation study was carried out involving ten sires and 50 dams. The animals were mated over a period of 20 discrete generations. The population size was kept constant. Different situations with regard to the level of polymorphism and initial allele frequencies and mating scheme (random mating, avoidance of full sib mating, avoidance of full sib and half sib mating) were considered. Pedigree inbreeding coefficients of the last generation using full pedigree or 10, 5 and 2 generations of the pedigree were calculated. Marker inbreeding coefficients based on different sets of microsatellite loci were also investigated. Under random mating, pedigree-inbreeding coefficients are clearly more closely related to true autozygosity (i.e., the actual proportion of loci with alleles identical by descent) than marker-inbreeding coefficients. If mating is not random, the demands on the quality and quantity of pedigree records increase. Greater attention must be paid to the correct parentage of the animals. BioMed Central 2003-07-15 /pmc/articles/PMC2697993/ /pubmed/12927072 http://dx.doi.org/10.1186/1297-9686-35-5-369 Text en Copyright © 2003 INRA, EDP Sciences
spellingShingle Research
Roswitha, Baumung
Johann, Sölkner
Pedigree and marker information requirements to monitor genetic variability
title Pedigree and marker information requirements to monitor genetic variability
title_full Pedigree and marker information requirements to monitor genetic variability
title_fullStr Pedigree and marker information requirements to monitor genetic variability
title_full_unstemmed Pedigree and marker information requirements to monitor genetic variability
title_short Pedigree and marker information requirements to monitor genetic variability
title_sort pedigree and marker information requirements to monitor genetic variability
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697993/
https://www.ncbi.nlm.nih.gov/pubmed/12927072
http://dx.doi.org/10.1186/1297-9686-35-5-369
work_keys_str_mv AT roswithabaumung pedigreeandmarkerinformationrequirementstomonitorgeneticvariability
AT johannsolkner pedigreeandmarkerinformationrequirementstomonitorgeneticvariability