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Acute Necrotizing Encephalopathy in Korean Infants and Children: Imaging Findings and Diverse Clinical Outcome
OBJECTIVE: The purpose of our study was to describe acute necrotizing encephalopathy in Korean infants and children, and we sought to evaluate the prognostic factors. MATERIALS AND METHODS: Acute necrotizing encephalopathy was diagnosed in 14 Korean infants and children. We retrospectively analyzed...
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Formato: | Texto |
Lenguaje: | English |
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The Korean Radiological Society
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698159/ https://www.ncbi.nlm.nih.gov/pubmed/15467414 http://dx.doi.org/10.3348/kjr.2004.5.3.171 |
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author | Kim, Ji Hye Kim, In-One Lim, Myung Kwan Park, Man Soo Choi, Choong Gon Kim, Hye Won Kim, Jee Eun Choi, Soo Jin Koh, Young Hwan Yang, Dal Mo Choo, Sung Wook Chung, Myung Jin Yoon, Hye-Kyung Goo, Hyun Woo Lee, Munhyang |
author_facet | Kim, Ji Hye Kim, In-One Lim, Myung Kwan Park, Man Soo Choi, Choong Gon Kim, Hye Won Kim, Jee Eun Choi, Soo Jin Koh, Young Hwan Yang, Dal Mo Choo, Sung Wook Chung, Myung Jin Yoon, Hye-Kyung Goo, Hyun Woo Lee, Munhyang |
author_sort | Kim, Ji Hye |
collection | PubMed |
description | OBJECTIVE: The purpose of our study was to describe acute necrotizing encephalopathy in Korean infants and children, and we sought to evaluate the prognostic factors. MATERIALS AND METHODS: Acute necrotizing encephalopathy was diagnosed in 14 Korean infants and children. We retrospectively analyzed the neuroimaging findings including the follow-up changes. The clinical course of the disease was graded, and we evaluated prognostic factors including age, serum level of the aminotransferase, hemorrhage, and localized atrophy of the brain. RESULTS: This encephalopathy predominantly affected the bilateral thalami (n=14), pons (n=12), and midbrain (n=10) in a symmetrical pattern. Hemorrhage was observed in eight patients (57%). On the follow-up images (n=12), the brain lesions were reduced in extent for all patients, and generalized atrophy was seen in six patients. Localized tissue loss was observed in five patients and a complete resolution occurred for one patient. All the patients survived and two recovered completely; mild (n=6) to severe (n=6) neurological deficits persisted in the remaining 12 patients. The significant prognostic factors identified in this study were the presence of hemorrhage (p = 0.009) and localized atrophy (p = 0.015). CONCLUSION: Acute necrotizing encephalopathy in Korean patients showed the characteristic patterns of the post-infectious encephalopathy as described in the literature. The high survival rate and the relatively favorable clinical course observed for the present study suggest a more diverse spectrum of disease severity than was previously described. The presence of hemorrhage and localized tissue loss on MR images may suggest a poor prognosis. |
format | Text |
id | pubmed-2698159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | The Korean Radiological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-26981592009-06-23 Acute Necrotizing Encephalopathy in Korean Infants and Children: Imaging Findings and Diverse Clinical Outcome Kim, Ji Hye Kim, In-One Lim, Myung Kwan Park, Man Soo Choi, Choong Gon Kim, Hye Won Kim, Jee Eun Choi, Soo Jin Koh, Young Hwan Yang, Dal Mo Choo, Sung Wook Chung, Myung Jin Yoon, Hye-Kyung Goo, Hyun Woo Lee, Munhyang Korean J Radiol Original Article OBJECTIVE: The purpose of our study was to describe acute necrotizing encephalopathy in Korean infants and children, and we sought to evaluate the prognostic factors. MATERIALS AND METHODS: Acute necrotizing encephalopathy was diagnosed in 14 Korean infants and children. We retrospectively analyzed the neuroimaging findings including the follow-up changes. The clinical course of the disease was graded, and we evaluated prognostic factors including age, serum level of the aminotransferase, hemorrhage, and localized atrophy of the brain. RESULTS: This encephalopathy predominantly affected the bilateral thalami (n=14), pons (n=12), and midbrain (n=10) in a symmetrical pattern. Hemorrhage was observed in eight patients (57%). On the follow-up images (n=12), the brain lesions were reduced in extent for all patients, and generalized atrophy was seen in six patients. Localized tissue loss was observed in five patients and a complete resolution occurred for one patient. All the patients survived and two recovered completely; mild (n=6) to severe (n=6) neurological deficits persisted in the remaining 12 patients. The significant prognostic factors identified in this study were the presence of hemorrhage (p = 0.009) and localized atrophy (p = 0.015). CONCLUSION: Acute necrotizing encephalopathy in Korean patients showed the characteristic patterns of the post-infectious encephalopathy as described in the literature. The high survival rate and the relatively favorable clinical course observed for the present study suggest a more diverse spectrum of disease severity than was previously described. The presence of hemorrhage and localized tissue loss on MR images may suggest a poor prognosis. The Korean Radiological Society 2004 2004-09-30 /pmc/articles/PMC2698159/ /pubmed/15467414 http://dx.doi.org/10.3348/kjr.2004.5.3.171 Text en Copyright © 2004 The Korean Radiological Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Ji Hye Kim, In-One Lim, Myung Kwan Park, Man Soo Choi, Choong Gon Kim, Hye Won Kim, Jee Eun Choi, Soo Jin Koh, Young Hwan Yang, Dal Mo Choo, Sung Wook Chung, Myung Jin Yoon, Hye-Kyung Goo, Hyun Woo Lee, Munhyang Acute Necrotizing Encephalopathy in Korean Infants and Children: Imaging Findings and Diverse Clinical Outcome |
title | Acute Necrotizing Encephalopathy in Korean Infants and Children: Imaging Findings and Diverse Clinical Outcome |
title_full | Acute Necrotizing Encephalopathy in Korean Infants and Children: Imaging Findings and Diverse Clinical Outcome |
title_fullStr | Acute Necrotizing Encephalopathy in Korean Infants and Children: Imaging Findings and Diverse Clinical Outcome |
title_full_unstemmed | Acute Necrotizing Encephalopathy in Korean Infants and Children: Imaging Findings and Diverse Clinical Outcome |
title_short | Acute Necrotizing Encephalopathy in Korean Infants and Children: Imaging Findings and Diverse Clinical Outcome |
title_sort | acute necrotizing encephalopathy in korean infants and children: imaging findings and diverse clinical outcome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698159/ https://www.ncbi.nlm.nih.gov/pubmed/15467414 http://dx.doi.org/10.3348/kjr.2004.5.3.171 |
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