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Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders

BACKGROUND: Children with Fetal Alcohol Spectrum Disorders (FASD) may have significant neurobehavioural problems persisting into adulthood. Early diagnosis may decrease the risk of adverse life outcomes. However, little is known about effective interventions for children with FASD. Our aim is to con...

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Autores principales: Peadon, Elizabeth, Rhys-Jones, Biarta, Bower, Carol, Elliott, Elizabeth J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698825/
https://www.ncbi.nlm.nih.gov/pubmed/19463198
http://dx.doi.org/10.1186/1471-2431-9-35
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author Peadon, Elizabeth
Rhys-Jones, Biarta
Bower, Carol
Elliott, Elizabeth J
author_facet Peadon, Elizabeth
Rhys-Jones, Biarta
Bower, Carol
Elliott, Elizabeth J
author_sort Peadon, Elizabeth
collection PubMed
description BACKGROUND: Children with Fetal Alcohol Spectrum Disorders (FASD) may have significant neurobehavioural problems persisting into adulthood. Early diagnosis may decrease the risk of adverse life outcomes. However, little is known about effective interventions for children with FASD. Our aim is to conduct a systematic review of the literature to identify and evaluate the evidence for pharmacological and non-pharmacological interventions for children with FASD. METHODS: We did an electronic search of the Cochrane Library, MEDLINE, EMBASE, PsychINFO, CINAHL and ERIC for clinical studies (Randomized controlled trials (RCT), quasi RCT, controlled trials and pre- and post-intervention studies) which evaluated pharmacological, behavioural, speech therapy, occupational therapy, physiotherapy, psychosocial and educational interventions and early intervention programs. Participants were aged under 18 years with a diagnosis of a FASD. Selection of studies for inclusion and assessment of study quality was undertaken independently by two reviewers. Meta-analysis was not possible due to diversity in the interventions and outcome measures. RESULTS: Twelve studies met the inclusion criteria. Methodological weaknesses were common, including small sample sizes; inadequate study design and short term follow up. Pharmacological interventions, evaluated in two studies (both RCT) showed some benefit from stimulant medications. Educational and learning strategies (three RCT) were evaluated in seven studies. There was some evidence to suggest that virtual reality training, cognitive control therapy, language and literacy therapy, mathematics intervention and rehearsal training for memory may be beneficial strategies. Three studies evaluating social communication and behavioural strategies (two RCT) suggested that social skills training may improve social skills and behaviour at home and Attention Process Training may improve attention. CONCLUSION: There is limited good quality evidence for specific interventions for managing FASD, however seven randomized controlled trials that address specific functional deficits of children with FASD are underway or recently completed.
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spelling pubmed-26988252009-06-19 Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders Peadon, Elizabeth Rhys-Jones, Biarta Bower, Carol Elliott, Elizabeth J BMC Pediatr Research Article BACKGROUND: Children with Fetal Alcohol Spectrum Disorders (FASD) may have significant neurobehavioural problems persisting into adulthood. Early diagnosis may decrease the risk of adverse life outcomes. However, little is known about effective interventions for children with FASD. Our aim is to conduct a systematic review of the literature to identify and evaluate the evidence for pharmacological and non-pharmacological interventions for children with FASD. METHODS: We did an electronic search of the Cochrane Library, MEDLINE, EMBASE, PsychINFO, CINAHL and ERIC for clinical studies (Randomized controlled trials (RCT), quasi RCT, controlled trials and pre- and post-intervention studies) which evaluated pharmacological, behavioural, speech therapy, occupational therapy, physiotherapy, psychosocial and educational interventions and early intervention programs. Participants were aged under 18 years with a diagnosis of a FASD. Selection of studies for inclusion and assessment of study quality was undertaken independently by two reviewers. Meta-analysis was not possible due to diversity in the interventions and outcome measures. RESULTS: Twelve studies met the inclusion criteria. Methodological weaknesses were common, including small sample sizes; inadequate study design and short term follow up. Pharmacological interventions, evaluated in two studies (both RCT) showed some benefit from stimulant medications. Educational and learning strategies (three RCT) were evaluated in seven studies. There was some evidence to suggest that virtual reality training, cognitive control therapy, language and literacy therapy, mathematics intervention and rehearsal training for memory may be beneficial strategies. Three studies evaluating social communication and behavioural strategies (two RCT) suggested that social skills training may improve social skills and behaviour at home and Attention Process Training may improve attention. CONCLUSION: There is limited good quality evidence for specific interventions for managing FASD, however seven randomized controlled trials that address specific functional deficits of children with FASD are underway or recently completed. BioMed Central 2009-05-25 /pmc/articles/PMC2698825/ /pubmed/19463198 http://dx.doi.org/10.1186/1471-2431-9-35 Text en Copyright © 2009 Peadon et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Peadon, Elizabeth
Rhys-Jones, Biarta
Bower, Carol
Elliott, Elizabeth J
Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders
title Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders
title_full Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders
title_fullStr Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders
title_full_unstemmed Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders
title_short Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders
title_sort systematic review of interventions for children with fetal alcohol spectrum disorders
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698825/
https://www.ncbi.nlm.nih.gov/pubmed/19463198
http://dx.doi.org/10.1186/1471-2431-9-35
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