Cargando…

A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice

BACKGROUND: The mammalian target of rapamycin protein (mTOR) is an evolutionarily conserved kinase that regulates protein synthesis, cell cycle progression and proliferation in response to various environmental cues. As a critical downstream mediator of PI3K signaling, mTOR is important for lymphocy...

Descripción completa

Detalles Bibliográficos
Autores principales: Shor, Boris, Cavender, Druie, Harris, Crafford
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698930/
https://www.ncbi.nlm.nih.gov/pubmed/19457267
http://dx.doi.org/10.1186/1471-2172-10-28

Ejemplares similares