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Cytosolic PLA(2) is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15
IL-15 and NKG2D promote autoimmunity and celiac disease by arming cytotoxic T lymphocytes (CTLs) to cause tissue destruction. However, the downstream signaling events underlying these functional properties remain unclear. Here, we identify cytosolic phospholipase A(2) (cPLA(2)) as a central molecule...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699120/ https://www.ncbi.nlm.nih.gov/pubmed/19237603 http://dx.doi.org/10.1084/jem.20071887 |