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Cytosolic PLA(2) is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15

IL-15 and NKG2D promote autoimmunity and celiac disease by arming cytotoxic T lymphocytes (CTLs) to cause tissue destruction. However, the downstream signaling events underlying these functional properties remain unclear. Here, we identify cytosolic phospholipase A(2) (cPLA(2)) as a central molecule...

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Detalles Bibliográficos
Autores principales:	Tang, Fangming, Chen, Zhangguo, Ciszewski, Cezary, Setty, Mala, Solus, Jason, Tretiakova, Maria, Ebert, Ellen, Han, Jin, Lin, Anning, Guandalini, Stefano, Groh, Veronika, Spies, Thomas, Green, Peter, Jabri, Bana
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699120/ https://www.ncbi.nlm.nih.gov/pubmed/19237603 http://dx.doi.org/10.1084/jem.20071887

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