Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryp...

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Autores principales: Means, Terry K., Mylonakis, Eleftherios, Tampakakis, Emmanouil, Colvin, Richard A., Seung, Edward, Puckett, Lindsay, Tai, Melissa F., Stewart, Cameron R., Pukkila-Worley, Read, Hickman, Suzanne E., Moore, Kathryn J., Calderwood, Stephen B., Hacohen, Nir, Luster, Andrew D., El Khoury, Joseph
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699123/
https://www.ncbi.nlm.nih.gov/pubmed/19237602
http://dx.doi.org/10.1084/jem.20082109
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author Means, Terry K.
Mylonakis, Eleftherios
Tampakakis, Emmanouil
Colvin, Richard A.
Seung, Edward
Puckett, Lindsay
Tai, Melissa F.
Stewart, Cameron R.
Pukkila-Worley, Read
Hickman, Suzanne E.
Moore, Kathryn J.
Calderwood, Stephen B.
Hacohen, Nir
Luster, Andrew D.
El Khoury, Joseph
author_facet Means, Terry K.
Mylonakis, Eleftherios
Tampakakis, Emmanouil
Colvin, Richard A.
Seung, Edward
Puckett, Lindsay
Tai, Melissa F.
Stewart, Cameron R.
Pukkila-Worley, Read
Hickman, Suzanne E.
Moore, Kathryn J.
Calderwood, Stephen B.
Hacohen, Nir
Luster, Andrew D.
El Khoury, Joseph
author_sort Means, Terry K.
collection PubMed
description Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans. CED-1 and C03F11.1 mediated antimicrobial peptide production and were necessary for nematode survival after C. neoformans infection. SCARF1 and CD36 mediated cytokine production and were required for macrophage binding to C. neoformans, and control of the infection in mice. Binding of these pathogens to SCARF1 and CD36 was β-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are β-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.
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spelling pubmed-26991232009-09-16 Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 Means, Terry K. Mylonakis, Eleftherios Tampakakis, Emmanouil Colvin, Richard A. Seung, Edward Puckett, Lindsay Tai, Melissa F. Stewart, Cameron R. Pukkila-Worley, Read Hickman, Suzanne E. Moore, Kathryn J. Calderwood, Stephen B. Hacohen, Nir Luster, Andrew D. El Khoury, Joseph J Exp Med Article Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans. CED-1 and C03F11.1 mediated antimicrobial peptide production and were necessary for nematode survival after C. neoformans infection. SCARF1 and CD36 mediated cytokine production and were required for macrophage binding to C. neoformans, and control of the infection in mice. Binding of these pathogens to SCARF1 and CD36 was β-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are β-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens. The Rockefeller University Press 2009-03-16 /pmc/articles/PMC2699123/ /pubmed/19237602 http://dx.doi.org/10.1084/jem.20082109 Text en © 2009 Means et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Article
Means, Terry K.
Mylonakis, Eleftherios
Tampakakis, Emmanouil
Colvin, Richard A.
Seung, Edward
Puckett, Lindsay
Tai, Melissa F.
Stewart, Cameron R.
Pukkila-Worley, Read
Hickman, Suzanne E.
Moore, Kathryn J.
Calderwood, Stephen B.
Hacohen, Nir
Luster, Andrew D.
El Khoury, Joseph
Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
title Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
title_full Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
title_fullStr Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
title_full_unstemmed Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
title_short Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
title_sort evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors scarf1 and cd36
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699123/
https://www.ncbi.nlm.nih.gov/pubmed/19237602
http://dx.doi.org/10.1084/jem.20082109
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