Adenosine closes the K(+) channel K(Ca)3.1 in human lung mast cells and inhibits their migration via the adenosine A(2A) receptor

Human lung mast cells (HLMC) express the Ca(2+)-activated K(+) channel K(Ca)3.1, which opens following IgE-dependent activation. This hyperpolarises the cell membrane and potentiates both Ca(2+) influx and degranulation. In addition, blockade of K(Ca)3.1 profoundly inhibits HLMC migration to a varie...

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Detalles Bibliográficos
Autores principales: Duffy, S Mark, Cruse, Glenn, Brightling, Christopher E, Bradding, Peter
Formato: Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2007
Materias:
Leukocyte signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699420/
https://www.ncbi.nlm.nih.gov/pubmed/17474152
http://dx.doi.org/10.1002/eji.200637024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699420/
https://www.ncbi.nlm.nih.gov/pubmed/17474152
http://dx.doi.org/10.1002/eji.200637024

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