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Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

CD8(+) cytotoxic T lymphocytes (CTL) are key determinants of immunity to intracellular pathogens and neoplastic cells. Recognition of specific antigens in the form of peptide-MHC class I complexes (pMHCI) presented on the target cell surface is mediated by T cell receptor (TCR) engagement. The CD8 c...

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Detalles Bibliográficos
Autores principales:	Wooldridge, Linda, Lissina, Anna, Vernazza, Jonathan, Gostick, Emma, Laugel, Bruno, Hutchinson, Sarah L, Mirza, Fareed, Dunbar, P Rod, Boulter, Jonathan M, Glick, Meir, Cerundolo, Vincenzo, van den Berg, Hugo A, Price, David A, Sewell, Andrew K
Formato:	Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2007
Materias:	Immunomodulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699427/ https://www.ncbi.nlm.nih.gov/pubmed/17429845 http://dx.doi.org/10.1002/eji.200636765

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