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Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid
A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H(2)O]Cl·3H(2)O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry s...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699492/ https://www.ncbi.nlm.nih.gov/pubmed/19557138 http://dx.doi.org/10.1155/2009/603651 |
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author | Bivián-Castro, Egla Yareth López, Mercedes G. Pedraza-Reyes, Mario Bernès, Sylvain Mendoza-Díaz, Guillermo |
author_facet | Bivián-Castro, Egla Yareth López, Mercedes G. Pedraza-Reyes, Mario Bernès, Sylvain Mendoza-Díaz, Guillermo |
author_sort | Bivián-Castro, Egla Yareth |
collection | PubMed |
description | A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H(2)O]Cl·3H(2)O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry surrounded by two N atoms from hsm, two O atoms from the quinolone, and one apical water oxygen. Alteration of bacterial DNA structure and/or associated functions in vivo by [Cu(hsm)(nal)H(2)O]Cl·3H(2)O was demonstrated by the induction of a recA-lacZ fusion integrated at the amyE locus of a recombinant Bacillus subtilis strain. Results from circular dichroism and denaturation of calf thymus DNA (CT-DNA) suggested that increased amounts of copper complex were able to stabilize the double helix of DNA in vitro mainly by formation of hydrogen bonds between chn and the sugars of DNA minor groove. In vivo and in vitro biological activities of the chn complex were compared with the chemical nuclease [Cu(phen)(nal)H(2)O]NO(3) · 3H(2)O (cpn) where phen is phenanthroline. |
format | Text |
id | pubmed-2699492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-26994922009-06-24 Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid Bivián-Castro, Egla Yareth López, Mercedes G. Pedraza-Reyes, Mario Bernès, Sylvain Mendoza-Díaz, Guillermo Bioinorg Chem Appl Research Article A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H(2)O]Cl·3H(2)O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry surrounded by two N atoms from hsm, two O atoms from the quinolone, and one apical water oxygen. Alteration of bacterial DNA structure and/or associated functions in vivo by [Cu(hsm)(nal)H(2)O]Cl·3H(2)O was demonstrated by the induction of a recA-lacZ fusion integrated at the amyE locus of a recombinant Bacillus subtilis strain. Results from circular dichroism and denaturation of calf thymus DNA (CT-DNA) suggested that increased amounts of copper complex were able to stabilize the double helix of DNA in vitro mainly by formation of hydrogen bonds between chn and the sugars of DNA minor groove. In vivo and in vitro biological activities of the chn complex were compared with the chemical nuclease [Cu(phen)(nal)H(2)O]NO(3) · 3H(2)O (cpn) where phen is phenanthroline. Hindawi Publishing Corporation 2009 2009-06-18 /pmc/articles/PMC2699492/ /pubmed/19557138 http://dx.doi.org/10.1155/2009/603651 Text en Copyright © 2009 Egla Yareth Bivián-Castro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bivián-Castro, Egla Yareth López, Mercedes G. Pedraza-Reyes, Mario Bernès, Sylvain Mendoza-Díaz, Guillermo Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
title | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
title_full | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
title_fullStr | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
title_full_unstemmed | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
title_short | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
title_sort | synthesis, characterization, and biological activity studies of copper(ii) mixed compound with histamine and nalidixic acid |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699492/ https://www.ncbi.nlm.nih.gov/pubmed/19557138 http://dx.doi.org/10.1155/2009/603651 |
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