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Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition

We describe a strategy for constructing atomic resolution dynamical ensembles of RNA molecules, spanning up to millisecond timescales, that combines molecular dynamics (MD) simulations with NMR residual dipolar couplings (RDC) measured in elongated RNA. The ensembles are generated via a Monte Carlo...

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Detalles Bibliográficos
Autores principales:	Frank, Aaron T., Stelzer, Andrew C., Al-Hashimi, Hashim M., Andricioaei, Ioan
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699496/ https://www.ncbi.nlm.nih.gov/pubmed/19369218 http://dx.doi.org/10.1093/nar/gkp156

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