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Nontarget DNA binding shapes the dynamic landscape for enzymatic recognition of DNA damage

The DNA repair enzyme human uracil DNA glycosylase (UNG) scans short stretches of genomic DNA and captures rare uracil bases as they transiently emerge from the DNA duplex via spontaneous base pair breathing motions. The process of DNA scanning requires that the enzyme transiently loosen its grip on...

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Detalles Bibliográficos
Autores principales:	Friedman, Joshua I., Majumdar, Ananya, Stivers, James T.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Nucleic Acids Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699497/ https://www.ncbi.nlm.nih.gov/pubmed/19339520 http://dx.doi.org/10.1093/nar/gkp161

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