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Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

Poly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR) using nicotinamide adenine dinucleotide (NAD) as a substrate. Despite intensive research on the cellular functions of PARP1, the molecular mechanism of PAR formation has not been comprehensively understood. In this study, we el...

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Detalles Bibliográficos
Autores principales:	Altmeyer, Matthias, Messner, Simon, Hassa, Paul O., Fey, Monika, Hottiger, Michael O.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Nucleic Acids Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699514/ https://www.ncbi.nlm.nih.gov/pubmed/19372272 http://dx.doi.org/10.1093/nar/gkp229

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