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Predicting the Distribution of Spiral Waves from Cell Properties in a Developmental-Path Model of Dictyostelium Pattern Formation

The slime mold Dictyostelium discoideum is one of the model systems of biological pattern formation. One of the most successful answers to the challenge of establishing a spiral wave pattern in a colony of homogeneously distributed D. discoideum cells has been the suggestion of a developmental path...

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Detalles Bibliográficos
Autores principales: Geberth, Daniel, Hütt, Marc-Thorsten
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699541/
https://www.ncbi.nlm.nih.gov/pubmed/19593362
http://dx.doi.org/10.1371/journal.pcbi.1000422
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author Geberth, Daniel
Hütt, Marc-Thorsten
author_facet Geberth, Daniel
Hütt, Marc-Thorsten
author_sort Geberth, Daniel
collection PubMed
description The slime mold Dictyostelium discoideum is one of the model systems of biological pattern formation. One of the most successful answers to the challenge of establishing a spiral wave pattern in a colony of homogeneously distributed D. discoideum cells has been the suggestion of a developmental path the cells follow (Lauzeral and coworkers). This is a well-defined change in properties each cell undergoes on a longer time scale than the typical dynamics of the cell. Here we show that this concept leads to an inhomogeneous and systematic spatial distribution of spiral waves, which can be predicted from the distribution of cells on the developmental path. We propose specific experiments for checking whether such systematics are also found in data and thus, indirectly, provide evidence of a developmental path.
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spelling pubmed-26995412009-07-10 Predicting the Distribution of Spiral Waves from Cell Properties in a Developmental-Path Model of Dictyostelium Pattern Formation Geberth, Daniel Hütt, Marc-Thorsten PLoS Comput Biol Research Article The slime mold Dictyostelium discoideum is one of the model systems of biological pattern formation. One of the most successful answers to the challenge of establishing a spiral wave pattern in a colony of homogeneously distributed D. discoideum cells has been the suggestion of a developmental path the cells follow (Lauzeral and coworkers). This is a well-defined change in properties each cell undergoes on a longer time scale than the typical dynamics of the cell. Here we show that this concept leads to an inhomogeneous and systematic spatial distribution of spiral waves, which can be predicted from the distribution of cells on the developmental path. We propose specific experiments for checking whether such systematics are also found in data and thus, indirectly, provide evidence of a developmental path. Public Library of Science 2009-07-10 /pmc/articles/PMC2699541/ /pubmed/19593362 http://dx.doi.org/10.1371/journal.pcbi.1000422 Text en Geberth, Hütt. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Geberth, Daniel
Hütt, Marc-Thorsten
Predicting the Distribution of Spiral Waves from Cell Properties in a Developmental-Path Model of Dictyostelium Pattern Formation
title Predicting the Distribution of Spiral Waves from Cell Properties in a Developmental-Path Model of Dictyostelium Pattern Formation
title_full Predicting the Distribution of Spiral Waves from Cell Properties in a Developmental-Path Model of Dictyostelium Pattern Formation
title_fullStr Predicting the Distribution of Spiral Waves from Cell Properties in a Developmental-Path Model of Dictyostelium Pattern Formation
title_full_unstemmed Predicting the Distribution of Spiral Waves from Cell Properties in a Developmental-Path Model of Dictyostelium Pattern Formation
title_short Predicting the Distribution of Spiral Waves from Cell Properties in a Developmental-Path Model of Dictyostelium Pattern Formation
title_sort predicting the distribution of spiral waves from cell properties in a developmental-path model of dictyostelium pattern formation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699541/
https://www.ncbi.nlm.nih.gov/pubmed/19593362
http://dx.doi.org/10.1371/journal.pcbi.1000422
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