Pig Embryonic Pancreatic Tissue as a Source for Transplantation in Diabetes: Transient Treatment With Anti-LFA1, Anti-CD48, and FTY720 Enables Long-Term Graft Maintenance in Mice With Only Mild Ongoing Immunosuppression

OBJECTIVE: Defining an optimal costimulatory blockade–based immune suppression protocol enabling engraftment and functional development of E42 pig embryonic pancreatic tissue in mice. RESEARCH DESIGN AND METHODS: Considering that anti-CD40L was found to be thrombotic in humans, we sought to test alt...

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Detalles Bibliográficos
Autores principales: Tchorsh-Yutsis, Dalit, Hecht, Gil, Aronovich, Anna, Shezen, Elias, Klionsky, Yael, Rosen, Chava, Bitcover, Rivka, Eventov-Friedman, Smadar, Katchman, Helena, Cohen, Sivan, Tal, Orna, Milstein, Oren, Yagita, Hideo, Blazar, Bruce R., Reisner, Yair
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699862/
https://www.ncbi.nlm.nih.gov/pubmed/19401429
http://dx.doi.org/10.2337/db09-0112

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