Cargando…
Factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation study
BACKGROUND: Low bone mass is common in end-stage renal disease patients, especially those undergoing hemodialysis. It can lead to serious bone health problems such as fragility fractures. The purpose of this study is to investigate the risk factors of low bone mass in the hemodialysis patients. METH...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700075/ https://www.ncbi.nlm.nih.gov/pubmed/19497099 http://dx.doi.org/10.1186/1471-2474-10-60 |
_version_ | 1782168568879644672 |
---|---|
author | Huang, Guey-Shiun Chu, Tzong-Shinn Lou, Meei-Fang Hwang, Shiow-Li Yang, Rong-Sen |
author_facet | Huang, Guey-Shiun Chu, Tzong-Shinn Lou, Meei-Fang Hwang, Shiow-Li Yang, Rong-Sen |
author_sort | Huang, Guey-Shiun |
collection | PubMed |
description | BACKGROUND: Low bone mass is common in end-stage renal disease patients, especially those undergoing hemodialysis. It can lead to serious bone health problems such as fragility fractures. The purpose of this study is to investigate the risk factors of low bone mass in the hemodialysis patients. METHODS: Sixty-three subjects on hemodialysis for at least 6 months were recruited from a single center for this cross-sectional study. We collected data by questionnaire survey and medical records review. All subjects underwent a bone mineral density (BMD) assay with dual-energy x-ray absorptiometry at the lumbar spine and right hip. Data were statistically analyzed by means of descriptive analysis, independent t test and one way analysis of variance for continuous variables, Pearson product-moment correlation to explore the correlated factors of BMD, and stepwise multiple linear regression to identify the predictors of low bone mass. RESULTS: Using WHO criteria as a cutoff point, fifty-one subjects (81%) had a T-score lower than -1, of them 8 subjects (13%) had osteoporosis with the femoral neck most commonly affected. Regarding risk factors, age, serum alkaline phosphatase (ALP) level, and intact parathyroid hormone (iPTH) level had significant negative correlations with the femoral neck and lumbar spine BMD. On the other hand, serum albumin level, effective exercise time, and body weight (BW) had significant positive correlations with the femoral neck and lumbar spine BMD. Age, effective exercise time, and serum albumin level significantly predicted the femoral neck BMD (R(2 )× 0.25), whereas BW and the ALP level significantly predicted the lumbar spine BMD (R(2 )× 0.20). CONCLUSION: This study showed that advanced age, low BW, low serum albumin level, and high ALP and iPTH levels were associated with a low bone mass in the hemodialysis patients. We suggest that regular monitoring of the femoral neck BMD, maintaining an adequate serum albumin level and BW, and undertaking an exercise program are important to improve bone health in the patients undergoing hemodialysis. |
format | Text |
id | pubmed-2700075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27000752009-06-23 Factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation study Huang, Guey-Shiun Chu, Tzong-Shinn Lou, Meei-Fang Hwang, Shiow-Li Yang, Rong-Sen BMC Musculoskelet Disord Research Article BACKGROUND: Low bone mass is common in end-stage renal disease patients, especially those undergoing hemodialysis. It can lead to serious bone health problems such as fragility fractures. The purpose of this study is to investigate the risk factors of low bone mass in the hemodialysis patients. METHODS: Sixty-three subjects on hemodialysis for at least 6 months were recruited from a single center for this cross-sectional study. We collected data by questionnaire survey and medical records review. All subjects underwent a bone mineral density (BMD) assay with dual-energy x-ray absorptiometry at the lumbar spine and right hip. Data were statistically analyzed by means of descriptive analysis, independent t test and one way analysis of variance for continuous variables, Pearson product-moment correlation to explore the correlated factors of BMD, and stepwise multiple linear regression to identify the predictors of low bone mass. RESULTS: Using WHO criteria as a cutoff point, fifty-one subjects (81%) had a T-score lower than -1, of them 8 subjects (13%) had osteoporosis with the femoral neck most commonly affected. Regarding risk factors, age, serum alkaline phosphatase (ALP) level, and intact parathyroid hormone (iPTH) level had significant negative correlations with the femoral neck and lumbar spine BMD. On the other hand, serum albumin level, effective exercise time, and body weight (BW) had significant positive correlations with the femoral neck and lumbar spine BMD. Age, effective exercise time, and serum albumin level significantly predicted the femoral neck BMD (R(2 )× 0.25), whereas BW and the ALP level significantly predicted the lumbar spine BMD (R(2 )× 0.20). CONCLUSION: This study showed that advanced age, low BW, low serum albumin level, and high ALP and iPTH levels were associated with a low bone mass in the hemodialysis patients. We suggest that regular monitoring of the femoral neck BMD, maintaining an adequate serum albumin level and BW, and undertaking an exercise program are important to improve bone health in the patients undergoing hemodialysis. BioMed Central 2009-06-04 /pmc/articles/PMC2700075/ /pubmed/19497099 http://dx.doi.org/10.1186/1471-2474-10-60 Text en Copyright © 2009 Huang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Huang, Guey-Shiun Chu, Tzong-Shinn Lou, Meei-Fang Hwang, Shiow-Li Yang, Rong-Sen Factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation study |
title | Factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation study |
title_full | Factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation study |
title_fullStr | Factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation study |
title_full_unstemmed | Factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation study |
title_short | Factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation study |
title_sort | factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700075/ https://www.ncbi.nlm.nih.gov/pubmed/19497099 http://dx.doi.org/10.1186/1471-2474-10-60 |
work_keys_str_mv | AT huanggueyshiun factorsassociatedwithlowbonemassinthehemodialysispatientsacrosssectionalcorrelationstudy AT chutzongshinn factorsassociatedwithlowbonemassinthehemodialysispatientsacrosssectionalcorrelationstudy AT loumeeifang factorsassociatedwithlowbonemassinthehemodialysispatientsacrosssectionalcorrelationstudy AT hwangshiowli factorsassociatedwithlowbonemassinthehemodialysispatientsacrosssectionalcorrelationstudy AT yangrongsen factorsassociatedwithlowbonemassinthehemodialysispatientsacrosssectionalcorrelationstudy |