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Distinct Roles of Non-Canonical Poly(A) Polymerases in RNA Metabolism
Trf4p and Trf5p are non-canonical poly(A) polymerases and are part of the heteromeric protein complexes TRAMP4 and TRAMP5 that promote the degradation of aberrant and short-lived RNA substrates by interacting with the nuclear exosome. To assess the level of functional redundancy between the paralogo...
Autores principales: | Paolo, Salvatore San, Vanacova, Stepanka, Schenk, Luca, Scherrer, Tanja, Blank, Diana, Keller, Walter, Gerber, André P. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700272/ https://www.ncbi.nlm.nih.gov/pubmed/19593367 http://dx.doi.org/10.1371/journal.pgen.1000555 |
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