Specific Loss of Histone H3 Lysine 9 Trimethylation and HP1γ/Cohesin Binding at D4Z4 Repeats Is Associated with Facioscapulohumeral Dystrophy (FSHD)

Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy in which no mutation of pathogenic gene(s) has been identified. Instead, the disease is, in most cases, genetically linked to a contraction in the number of 3.3 kb D4Z4 repeats on chromosome 4q. How contraction of the 4...

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Detalles Bibliográficos
Autores principales: Zeng, Weihua, de Greef, Jessica C., Chen, Yen-Yun, Chien, Richard, Kong, Xiangduo, Gregson, Heather C., Winokur, Sara T., Pyle, April, Robertson, Keith D., Schmiesing, John A., Kimonis, Virginia E., Balog, Judit, Frants, Rune R., Ball, Alexander R., Lock, Leslie F., Donovan, Peter J., van der Maarel, Silvère M., Yokomori, Kyoko
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700282/
https://www.ncbi.nlm.nih.gov/pubmed/19593370
http://dx.doi.org/10.1371/journal.pgen.1000559

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