The circuitry of cargo flux in the ESCRT pathway

The endosomal sorting complex required for transport (ESCRT) complexes sort ubiquitinated membrane proteins into multivesicular bodies, which is a key step in the lysosomal degradation pathway. Shields et al. (Shields, S.B., A.J. Oestreich, S. Winistorfer, D. Nguyen, J.A. Payne, D.J. Katzmann, and R...

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Detalles Bibliográficos
Autores principales: Hurley, James H., Ren, Xuefeng
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700367/
https://www.ncbi.nlm.nih.gov/pubmed/19380875
http://dx.doi.org/10.1083/jcb.200903013
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author Hurley, James H.
Ren, Xuefeng
author_facet Hurley, James H.
Ren, Xuefeng
author_sort Hurley, James H.
collection PubMed
description The endosomal sorting complex required for transport (ESCRT) complexes sort ubiquitinated membrane proteins into multivesicular bodies, which is a key step in the lysosomal degradation pathway. Shields et al. (Shields, S.B., A.J. Oestreich, S. Winistorfer, D. Nguyen, J.A. Payne, D.J. Katzmann, and R. Piper. 2009. J. Cell Biol. 185:213–224) identify a new ubiquitin-binding site in ESCRT-I and provide evidence that the upstream ESCRT-I and -II complexes sort cargo in parallel rather than in series.
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spelling pubmed-27003672009-10-20 The circuitry of cargo flux in the ESCRT pathway Hurley, James H. Ren, Xuefeng J Cell Biol Reviews The endosomal sorting complex required for transport (ESCRT) complexes sort ubiquitinated membrane proteins into multivesicular bodies, which is a key step in the lysosomal degradation pathway. Shields et al. (Shields, S.B., A.J. Oestreich, S. Winistorfer, D. Nguyen, J.A. Payne, D.J. Katzmann, and R. Piper. 2009. J. Cell Biol. 185:213–224) identify a new ubiquitin-binding site in ESCRT-I and provide evidence that the upstream ESCRT-I and -II complexes sort cargo in parallel rather than in series. The Rockefeller University Press 2009-04-20 /pmc/articles/PMC2700367/ /pubmed/19380875 http://dx.doi.org/10.1083/jcb.200903013 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Hurley, James H.
Ren, Xuefeng
The circuitry of cargo flux in the ESCRT pathway
title The circuitry of cargo flux in the ESCRT pathway
title_full The circuitry of cargo flux in the ESCRT pathway
title_fullStr The circuitry of cargo flux in the ESCRT pathway
title_full_unstemmed The circuitry of cargo flux in the ESCRT pathway
title_short The circuitry of cargo flux in the ESCRT pathway
title_sort circuitry of cargo flux in the escrt pathway
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700367/
https://www.ncbi.nlm.nih.gov/pubmed/19380875
http://dx.doi.org/10.1083/jcb.200903013
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