Oxidation by trace Cu(2+) ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery

Ascorbate has both antioxidant and pro-oxidant activities. We have previously shown that plasma levels of ascorbate induce constriction and blockade of dilatation mediated by endothelium-derived hyperpolarizing factor (EDHF). In this study we sought to determine if these detrimental actions were med...

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Detalles Bibliográficos
Autores principales: Nelli, Silvia, Craig, John, Martin, William
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2009
Materias:
Cardiovascular Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700718/
https://www.ncbi.nlm.nih.gov/pubmed/19394330
http://dx.doi.org/10.1016/j.ejphar.2009.04.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700718/
https://www.ncbi.nlm.nih.gov/pubmed/19394330
http://dx.doi.org/10.1016/j.ejphar.2009.04.033

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