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Oxidation by trace Cu(2+) ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery
Ascorbate has both antioxidant and pro-oxidant activities. We have previously shown that plasma levels of ascorbate induce constriction and blockade of dilatation mediated by endothelium-derived hyperpolarizing factor (EDHF). In this study we sought to determine if these detrimental actions were med...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700718/ https://www.ncbi.nlm.nih.gov/pubmed/19394330 http://dx.doi.org/10.1016/j.ejphar.2009.04.033 |