Characterization of Liposomes for Cancer Cell Transfection

We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposom...

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Detalles Bibliográficos
Autores principales: Tatarkova, Svetlana A, Khaira, Satvinder
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701086/
https://www.ncbi.nlm.nih.gov/pubmed/19662129
http://dx.doi.org/10.2174/1874120700701010060
Descripción
Sumario:We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposomes were tested by transfection of DNA in living cancer cells.

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