Characterization of Liposomes for Cancer Cell Transfection

We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposom...

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Detalles Bibliográficos
Autores principales: Tatarkova, Svetlana A, Khaira, Satvinder
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701086/
https://www.ncbi.nlm.nih.gov/pubmed/19662129
http://dx.doi.org/10.2174/1874120700701010060
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author Tatarkova, Svetlana A
Khaira, Satvinder
author_facet Tatarkova, Svetlana A
Khaira, Satvinder
author_sort Tatarkova, Svetlana A
collection PubMed
description We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposomes were tested by transfection of DNA in living cancer cells.
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spelling pubmed-27010862009-08-06 Characterization of Liposomes for Cancer Cell Transfection Tatarkova, Svetlana A Khaira, Satvinder Open Biomed Eng J Article We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposomes were tested by transfection of DNA in living cancer cells. Bentham Science Publishers Ltd. 2007-10-26 /pmc/articles/PMC2701086/ /pubmed/19662129 http://dx.doi.org/10.2174/1874120700701010060 Text en 2007 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Tatarkova, Svetlana A
Khaira, Satvinder
Characterization of Liposomes for Cancer Cell Transfection
title Characterization of Liposomes for Cancer Cell Transfection
title_full Characterization of Liposomes for Cancer Cell Transfection
title_fullStr Characterization of Liposomes for Cancer Cell Transfection
title_full_unstemmed Characterization of Liposomes for Cancer Cell Transfection
title_short Characterization of Liposomes for Cancer Cell Transfection
title_sort characterization of liposomes for cancer cell transfection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701086/
https://www.ncbi.nlm.nih.gov/pubmed/19662129
http://dx.doi.org/10.2174/1874120700701010060
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AT khairasatvinder characterizationofliposomesforcancercelltransfection

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