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Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure

The increase in serotonin (5-HT) neurotransmission is considered to be one of the most efficacious medical approach to depression and its related disorders. The selective serotonin reuptake inhibitors (SSRIs) represent the most widely antidepressive drugs utilized in the medical treatment of depress...

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Autores principales: Costagliola, Ciro, Parmeggiani, Francesco, Semeraro, Francesco, Sebastiani, Adolfo
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701282/
https://www.ncbi.nlm.nih.gov/pubmed/19587851
http://dx.doi.org/10.2174/157015908787386104
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author Costagliola, Ciro
Parmeggiani, Francesco
Semeraro, Francesco
Sebastiani, Adolfo
author_facet Costagliola, Ciro
Parmeggiani, Francesco
Semeraro, Francesco
Sebastiani, Adolfo
author_sort Costagliola, Ciro
collection PubMed
description The increase in serotonin (5-HT) neurotransmission is considered to be one of the most efficacious medical approach to depression and its related disorders. The selective serotonin reuptake inhibitors (SSRIs) represent the most widely antidepressive drugs utilized in the medical treatment of depressed patients. Currently available SSRIs include fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram and escitalopram. The primary SSRIs pharmacological action’s mechanism consists in the presynaptic inhibition on the serotonin reuptake, with an increased availability of this amine into the synaptic cleft. Serotonin produces its effects as a consequence of interactions with appropriate receptors. Seven distinct families of 5-HT receptors have been identified (5-HT(1) to 5-HT(7)), and subpopulations have been described for several of these. The interaction between serotonin and post-synaptic receptors mediates a wide range of functions. The SSRIs have a very favorable safety profile, although clinical signs of several unexpected pathologic events are often misdiagnosed, in particular, those regarding the eye. In all cases reported in the literature the angle-closure glaucoma represents the most important SSRIs-related ocular adverse event. Thus, it is not quite hazardous to hypothesize that also the other reported and unspecified visual disturbances could be attributed - at least in some cases - to IOP modifications. The knowledge of SSRIs individual tolerability, angle-closure predisposition and critical IOP could be important goals able to avoid further and more dangerous ocular side effects.
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spelling pubmed-27012822009-07-08 Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure Costagliola, Ciro Parmeggiani, Francesco Semeraro, Francesco Sebastiani, Adolfo Curr Neuropharmacol Article The increase in serotonin (5-HT) neurotransmission is considered to be one of the most efficacious medical approach to depression and its related disorders. The selective serotonin reuptake inhibitors (SSRIs) represent the most widely antidepressive drugs utilized in the medical treatment of depressed patients. Currently available SSRIs include fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram and escitalopram. The primary SSRIs pharmacological action’s mechanism consists in the presynaptic inhibition on the serotonin reuptake, with an increased availability of this amine into the synaptic cleft. Serotonin produces its effects as a consequence of interactions with appropriate receptors. Seven distinct families of 5-HT receptors have been identified (5-HT(1) to 5-HT(7)), and subpopulations have been described for several of these. The interaction between serotonin and post-synaptic receptors mediates a wide range of functions. The SSRIs have a very favorable safety profile, although clinical signs of several unexpected pathologic events are often misdiagnosed, in particular, those regarding the eye. In all cases reported in the literature the angle-closure glaucoma represents the most important SSRIs-related ocular adverse event. Thus, it is not quite hazardous to hypothesize that also the other reported and unspecified visual disturbances could be attributed - at least in some cases - to IOP modifications. The knowledge of SSRIs individual tolerability, angle-closure predisposition and critical IOP could be important goals able to avoid further and more dangerous ocular side effects. Bentham Science Publishers Ltd. 2008-12 /pmc/articles/PMC2701282/ /pubmed/19587851 http://dx.doi.org/10.2174/157015908787386104 Text en ©2008 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Costagliola, Ciro
Parmeggiani, Francesco
Semeraro, Francesco
Sebastiani, Adolfo
Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure
title Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure
title_full Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure
title_fullStr Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure
title_full_unstemmed Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure
title_short Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure
title_sort selective serotonin reuptake inhibitors: a review of its effects on intraocular pressure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701282/
https://www.ncbi.nlm.nih.gov/pubmed/19587851
http://dx.doi.org/10.2174/157015908787386104
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