Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes

The prevalence of CD36 deficiency in East Asian and African populations suggests that the causal variants are under selection by severe malaria. Previous analysis of data from the International HapMap Project indicated that a CD36 haplotype bearing a nonsense mutation (T1264G; rs3211938) had undergo...

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Detalles Bibliográficos
Autores principales: Fry, Andrew E., Ghansa, Anita, Small, Kerrin S., Palma, Alejandro, Auburn, Sarah, Diakite, Mahamadou, Green, Angela, Campino, Susana, Teo, Yik Y., Clark, Taane G., Jeffreys, Anna E., Wilson, Jonathan, Jallow, Muminatou, Sisay-Joof, Fatou, Pinder, Margaret, Griffiths, Michael J., Peshu, Norbert, Williams, Thomas N., Newton, Charles R., Marsh, Kevin, Molyneux, Malcolm E., Taylor, Terrie E., Koram, Kwadwo A., Oduro, Abraham R., Rogers, William O., Rockett, Kirk A., Sabeti, Pardis C., Kwiatkowski, Dominic P.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Association Studies Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701331/
https://www.ncbi.nlm.nih.gov/pubmed/19403559
http://dx.doi.org/10.1093/hmg/ddp192

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