The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL)

von Hippel-Lindau (VHL) disease is caused by germ-line mutations in the VHL tumor suppressor gene and is the most common cause of inherited renal cell carcinoma (RCC). Mutations in the VHL gene also occur in a large majority of sporadic cases of clear-cell RCC, which have high intrinsic resistance t...

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Detalles Bibliográficos
Autores principales: Guo, Y, Schoell, MC, Freeman, RS
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701369/
https://www.ncbi.nlm.nih.gov/pubmed/19305426
http://dx.doi.org/10.1038/onc.2009.35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701369/
https://www.ncbi.nlm.nih.gov/pubmed/19305426
http://dx.doi.org/10.1038/onc.2009.35

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